What is Meridia and how is it used?
Meridia belongs to a class of drugs called Schedule IV controlled substances.
It is not known if Meridia is safe and effective in children younger than 16 years of age.
Is meridia still available
In October of 2010 the FDA requested that Abbott Laboratories—the manufacturer of Meridia—voluntarily withdraw this drug product from the United States market due to cardiovascular risks. Abbott agreed to voluntarily stop marketing of Meridia in the United States.
MERIDIA (sibutramine hydrochloride monohydrate) has been approved for the management of obesity, including weight loss and maintenance of weight loss, when used in conjunction with a reduced-calorie diet. You can buy meridia diet pills online without prescription overnight cheap.
Most side effects associated with MERIDIA are mild and transient in nature, including dry mouth, headache, constipation, and insomnia.
Mechanism of Action
MERIDIA works in a different manner than other prescription weight management medications. It is a neurotransmitter reuptake inhibitor that merely enhances the body’s normal function. MERIDIA is not a releasing agent. It does not get inside the cells to boost the release of neurotransmitters, such as serotonin. Instead, as a reuptake inhibitor, MERIDIA works outside the cells to stop neurotransmitters from being reabsorbed. MERIDIA works by affecting natural chemicals in the brain involved in regulating appetite–allowing them to act longer. The appetite control center in the brain is believed to regulate the amount of food eaten through feelings of hunger and fullness.
How effective is sibutramine (meridia)?
Adults taking sibutramine for 1 year are 19% to 34% more likely to achieve 5% weight loss and 12% to 31% more likely to achieve 10% weight loss than those taking placebo. Thus, clinicians would need to treat between 3 and 5 patients with sibutramine, 10 to 15 mg/d, for 1 year for one patient to achieve 5% weight loss.
DOSAGE AND ADMINISTRATION
The recommended starting dose of MERIDIA (sibutramine hydrochloride monohydrate) is 10 mg administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after four weeks to a total of 15 mg once daily. The 5 mg dose should be reserved for patients who do not tolerate the 10 mg dose. Blood pressure and heart rate changes should be taken into account when making decisions regarding dose titration (see WARNINGS and PRECAUTIONS).
Doses above 15 mg daily are not recommended. In most of the clinical trials, MERIDIA (sibutramine hydrochloride monohydrate) was given in the morning.
Analysis of numerous variable s has indicated that approximately 60% of patients who lose at least 4 pounds in the first 4 weeks of treatment with a given dose of MERIDIA (sibutramine hydrochloride monohydrate) in combination with a reduced-calorie diet lose at least 5% (placebo-subtracted) of their initial body weight by the end of 6 months to 1 year of treatment on that dose of MERIDIA (sibutramine hydrochloride monohydrate) . Conversely , approximately 80% of patients who do not lose at least 4 pounds in the first 4 weeks of treatment with a given dose of MERIDIA (sibutramine hydrochloride monohydrate) do not lose at least 5% (placebo-subtracted) of their initial body weight by the end of 6 months to 1 year of treatment on that dose. If a patient has not lost at least 4 pounds in the first 4 weeks of treatment, the physician should consider reevaluation of therapy which may include increasing the dose or discontinuation of MERIDIA (sibutramine hydrochloride monohydrate) .
The safety and effectiveness of MERIDIA (sibutramine hydrochloride monohydrate) , as demonstrated in double-blind, placebo-controlled trials, have not been determined beyond 2 years at this time.
MERIDIA® (sibutramine hydrochloride monohydrate) Capsules contain 5 mg, 10 mg, or 15 mg sibutramine hydrochloride monohydrate and are supplied as follows:
5 mg, NDC 0074-2456-12, blue/yellow capsules imprinted with “MERIDIA (sibutramine hydrochloride monohydrate) ” on the cap and ”-5-“ on the body, in bottles of 30 capsules.
10 mg, NDC 0074-2457-12, blue/white capsules imprinted with ”MERIDIA (sibutramine hydrochloride monohydrate) ” on the cap and “-10-” on the body, in bottles of 30 capsules.
15 mg, NDC 0074-2458-12, yellow/white capsules imprinted with “MERIDIA (sibutramine hydrochloride monohydrate) ” on the cap and “-15-” on the body, in bottles of 30 capsules.
Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP controlled room temperature]. Protect capsules from heat and moisture. Dispense in a tight, light-resistant container as defined in USP.
Comparing Meridia vs Phentermine
Prescribed for Obesity. Meridia may also be used for purposes not listed in this medication guide.
Phentermine may be used short-term as an aid to weight loss; however, it can be addictive and tolerance may develop to its weight-losing effects, rendering it less effective with time.
Prescribed for Weight Loss, Obesity.
phentermine may also be used for purposes not listed in this medication guide.